Born in Pescara, Sara Serraiocco developed from a young age a passion for dance and cinema, and she later worked as a dance teacher too (cut). She moved to Rome in 2010where she attended the Centro Sperimentale di Cinematografia, the Italian National Film School.
After appearing in one episode of crime series R.I.S. Roma, Serraiocco made her film debut in 2013, starring in (the feature film) Salvo, awarded The Critics' Week Grand Prix during 2013 Cannes Film Festival. Her performance as a blind girl brought up in the suburbs of Palermo got her several awards including the Italian Golden Globe for best actress and the "Guglielmo Biraghi" Nastro d'Argento as best new talent.
In 2014 she was picked by director Liliana Cavani to play the role of Saint Clare of Assisi in the mini series "Francesco".